Glycoproteomics in neurodegenerative diseases
Identifieur interne : 002153 ( Main/Corpus ); précédent : 002152; suivant : 002154Glycoproteomics in neurodegenerative diseases
Auteurs : Hyejin Hwang ; Jianpeng Zhang ; Kathryn A. Chung ; James B. Leverenz ; Cyrus P. Zabetian ; Elaine R. Peskind ; Joseph Jankovic ; Zhen Su ; Aneeka M. Hancock ; Catherine Pan ; Thomas J. Montine ; Sheng Pan ; John Nutt ; Roger Albin ; Marla Gearing ; Richard P. Beyer ; Min Shi ; Jing ZhangSource :
- Mass Spectrometry Reviews [ 0277-7037 ] ; 2010-01.
English descriptors
- KwdEn :
Abstract
Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry‐based technology to the study of neurodegenerative disorders (e.g., Alzheimer's disease and Parkinson's disease) is relatively new, and is expected to provide insight into the biochemical pathogenesis of neurodegeneration, as well as biomarker discovery. In this review, we have summarized the current understanding of glycoproteins in biology and neurodegenerative disease, and have discussed existing proteomic technologies that are utilized to characterize glycoproteins. Some of the ongoing studies, where glycoproteins isolated from cerebrospinal fluid and human brain are being characterized in Parkinson's disease at different stages versus controls, are presented, along with future applications of targeted validation of brain specific glycoproteins in body fluids. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:79–125, 2010
Url:
DOI: 10.1002/mas.20221
Links to Exploration step
ISTEX:39E49D67A31877FB13570FF15D84333251F02047Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glycoproteomics in neurodegenerative diseases</title><author><name sortKey="Hwang, Hyejin" sort="Hwang, Hyejin" uniqKey="Hwang H" first="Hyejin" last="Hwang">Hyejin Hwang</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Jianpeng" sort="Zhang, Jianpeng" uniqKey="Zhang J" first="Jianpeng" last="Zhang">Jianpeng Zhang</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><affiliation><mods:affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation><mods:affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Peskind, Elaine R" sort="Peskind, Elaine R" uniqKey="Peskind E" first="Elaine R." last="Peskind">Elaine R. Peskind</name><affiliation><mods:affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><mods:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Su, Zhen" sort="Su, Zhen" uniqKey="Su Z" first="Zhen" last="Su">Zhen Su</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Hancock, Aneeka M" sort="Hancock, Aneeka M" uniqKey="Hancock A" first="Aneeka M." last="Hancock">Aneeka M. Hancock</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Pan, Catherine" sort="Pan, Catherine" uniqKey="Pan C" first="Catherine" last="Pan">Catherine Pan</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Pan, Sheng" sort="Pan, Sheng" uniqKey="Pan S" first="Sheng" last="Pan">Sheng Pan</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Albin, Roger" sort="Albin, Roger" uniqKey="Albin R" first="Roger" last="Albin">Roger Albin</name><affiliation><mods:affiliation>Ann Arbor VAMC GRECC and Department of Neurology, University of Michigan, Ann Arbor, MI</mods:affiliation></affiliation></author><author><name sortKey="Gearing, Marla" sort="Gearing, Marla" uniqKey="Gearing M" first="Marla" last="Gearing">Marla Gearing</name><affiliation><mods:affiliation>Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA</mods:affiliation></affiliation></author><author><name sortKey="Beyer, Richard P" sort="Beyer, Richard P" uniqKey="Beyer R" first="Richard P." last="Beyer">Richard P. Beyer</name><affiliation><mods:affiliation>Department of Environmental & Occupational Health Sciences, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:39E49D67A31877FB13570FF15D84333251F02047</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mas.20221</idno><idno type="url">https://api.istex.fr/document/39E49D67A31877FB13570FF15D84333251F02047/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002153</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Glycoproteomics in neurodegenerative diseases</title><author><name sortKey="Hwang, Hyejin" sort="Hwang, Hyejin" uniqKey="Hwang H" first="Hyejin" last="Hwang">Hyejin Hwang</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Jianpeng" sort="Zhang, Jianpeng" uniqKey="Zhang J" first="Jianpeng" last="Zhang">Jianpeng Zhang</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><affiliation><mods:affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation><mods:affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Peskind, Elaine R" sort="Peskind, Elaine R" uniqKey="Peskind E" first="Elaine R." last="Peskind">Elaine R. Peskind</name><affiliation><mods:affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><mods:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Su, Zhen" sort="Su, Zhen" uniqKey="Su Z" first="Zhen" last="Su">Zhen Su</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Hancock, Aneeka M" sort="Hancock, Aneeka M" uniqKey="Hancock A" first="Aneeka M." last="Hancock">Aneeka M. Hancock</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Pan, Catherine" sort="Pan, Catherine" uniqKey="Pan C" first="Catherine" last="Pan">Catherine Pan</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Pan, Sheng" sort="Pan, Sheng" uniqKey="Pan S" first="Sheng" last="Pan">Sheng Pan</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Albin, Roger" sort="Albin, Roger" uniqKey="Albin R" first="Roger" last="Albin">Roger Albin</name><affiliation><mods:affiliation>Ann Arbor VAMC GRECC and Department of Neurology, University of Michigan, Ann Arbor, MI</mods:affiliation></affiliation></author><author><name sortKey="Gearing, Marla" sort="Gearing, Marla" uniqKey="Gearing M" first="Marla" last="Gearing">Marla Gearing</name><affiliation><mods:affiliation>Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA</mods:affiliation></affiliation></author><author><name sortKey="Beyer, Richard P" sort="Beyer, Richard P" uniqKey="Beyer R" first="Richard P." last="Beyer">Richard P. Beyer</name><affiliation><mods:affiliation>Department of Environmental & Occupational Health Sciences, University of Washington School of Medicine, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation><mods:affiliation>Department of Pathology, University of Washington, Seattle, WA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Mass Spectrometry Reviews</title><title level="j" type="abbrev">Mass Spectrom. Rev.</title><idno type="ISSN">0277-7037</idno><idno type="eISSN">1098-2787</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01">2010-01</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="79">79</biblScope><biblScope unit="page" to="125">125</biblScope></imprint><idno type="ISSN">0277-7037</idno></series><idno type="istex">39E49D67A31877FB13570FF15D84333251F02047</idno><idno type="DOI">10.1002/mas.20221</idno><idno type="ArticleID">MAS20221</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0277-7037</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's diseases</term><term>Parkinson's disease</term><term>biomarkers</term><term>cerebrospinal fluids</term><term>glycoproteomics</term><term>mass spectrometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry‐based technology to the study of neurodegenerative disorders (e.g., Alzheimer's disease and Parkinson's disease) is relatively new, and is expected to provide insight into the biochemical pathogenesis of neurodegeneration, as well as biomarker discovery. In this review, we have summarized the current understanding of glycoproteins in biology and neurodegenerative disease, and have discussed existing proteomic technologies that are utilized to characterize glycoproteins. Some of the ongoing studies, where glycoproteins isolated from cerebrospinal fluid and human brain are being characterized in Parkinson's disease at different stages versus controls, are presented, along with future applications of targeted validation of brain specific glycoproteins in body fluids. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:79–125, 2010</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hyejin Hwang</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Jianpeng Zhang</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Kathryn A. Chung</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, OR</json:string></affiliations></json:item><json:item><name>James B. Leverenz</name><affiliations><json:string>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</json:string><json:string>Department of Neurology, University of Washington School of Medicine, Seattle, WA</json:string></affiliations></json:item><json:item><name>Cyrus P. Zabetian</name><affiliations><json:string>Department of Neurology, University of Washington School of Medicine, Seattle, WA</json:string></affiliations></json:item><json:item><name>Elaine R. Peskind</name><affiliations><json:string>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</json:string><json:string>Department of Neurology, University of Washington School of Medicine, Seattle, WA</json:string></affiliations></json:item><json:item><name>Joseph Jankovic</name><affiliations><json:string>Department of Neurology, Baylor College of Medicine, Houston, TX</json:string></affiliations></json:item><json:item><name>Zhen Su</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Aneeka M. Hancock</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Catherine Pan</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Thomas J. Montine</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Sheng Pan</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>John Nutt</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, OR</json:string></affiliations></json:item><json:item><name>Roger Albin</name><affiliations><json:string>Ann Arbor VAMC GRECC and Department of Neurology, University of Michigan, Ann Arbor, MI</json:string></affiliations></json:item><json:item><name>Marla Gearing</name><affiliations><json:string>Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA</json:string></affiliations></json:item><json:item><name>Richard P. Beyer</name><affiliations><json:string>Department of Environmental & Occupational Health Sciences, University of Washington School of Medicine, Seattle, WA</json:string></affiliations></json:item><json:item><name>Min Shi</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Jing Zhang</name><affiliations><json:string>Department of Pathology, University of Washington, Seattle, WA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>glycoproteomics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mass spectrometry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer's diseases</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>biomarkers</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cerebrospinal fluids</value></json:item></subject><articleId><json:string>MAS20221</json:string></articleId><language><json:string>eng</json:string></language><abstract>Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry‐based technology to the study of neurodegenerative disorders (e.g., Alzheimer's disease and Parkinson's disease) is relatively new, and is expected to provide insight into the biochemical pathogenesis of neurodegeneration, as well as biomarker discovery. In this review, we have summarized the current understanding of glycoproteins in biology and neurodegenerative disease, and have discussed existing proteomic technologies that are utilized to characterize glycoproteins. Some of the ongoing studies, where glycoproteins isolated from cerebrospinal fluid and human brain are being characterized in Parkinson's disease at different stages versus controls, are presented, along with future applications of targeted validation of brain specific glycoproteins in body fluids. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:79–125, 2010</abstract><qualityIndicators><score>7.22</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1409</abstractCharCount><pdfWordCount>11546</pdfWordCount><pdfCharCount>78536</pdfCharCount><pdfPageCount>47</pdfPageCount><abstractWordCount>185</abstractWordCount></qualityIndicators><title>Glycoproteomics in neurodegenerative diseases</title><genre><json:string>review-article</json:string></genre><host><volume>29</volume><publisherId><json:string>MAS</json:string></publisherId><pages><total>47</total><last>125</last><first>79</first></pages><issn><json:string>0277-7037</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1098-2787</json:string></eissn><title>Mass Spectrometry Reviews</title><doi><json:string>10.1002/(ISSN)1098-2787</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mas.20221</json:string></doi><id>39E49D67A31877FB13570FF15D84333251F02047</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/39E49D67A31877FB13570FF15D84333251F02047/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/39E49D67A31877FB13570FF15D84333251F02047/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/39E49D67A31877FB13570FF15D84333251F02047/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Glycoproteomics in neurodegenerative diseases</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note>NIH - No. ES012703; No. NS057567; No. AG025327; No. AG033398; No. NS060252; No. AG05136; No. AG08671;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Glycoproteomics in neurodegenerative diseases</title><author><persName><forename type="first">Hyejin</forename><surname>Hwang</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">Jianpeng</forename><surname>Zhang</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">Kathryn A.</forename><surname>Chung</surname></persName><affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</affiliation></author><author><persName><forename type="first">James B.</forename><surname>Leverenz</surname></persName><affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</affiliation><affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</affiliation></author><author><persName><forename type="first">Cyrus P.</forename><surname>Zabetian</surname></persName><affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</affiliation></author><author><persName><forename type="first">Elaine R.</forename><surname>Peskind</surname></persName><affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</affiliation><affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</affiliation></author><author><persName><forename type="first">Joseph</forename><surname>Jankovic</surname></persName><affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX</affiliation></author><author><persName><forename type="first">Zhen</forename><surname>Su</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">Aneeka M.</forename><surname>Hancock</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">Catherine</forename><surname>Pan</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">Thomas J.</forename><surname>Montine</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">Sheng</forename><surname>Pan</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">John</forename><surname>Nutt</surname></persName><affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</affiliation></author><author><persName><forename type="first">Roger</forename><surname>Albin</surname></persName><affiliation>Ann Arbor VAMC GRECC and Department of Neurology, University of Michigan, Ann Arbor, MI</affiliation></author><author><persName><forename type="first">Marla</forename><surname>Gearing</surname></persName><affiliation>Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA</affiliation></author><author><persName><forename type="first">Richard P.</forename><surname>Beyer</surname></persName><affiliation>Department of Environmental & Occupational Health Sciences, University of Washington School of Medicine, Seattle, WA</affiliation></author><author><persName><forename type="first">Min</forename><surname>Shi</surname></persName><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author><author><persName><forename type="first">Jing</forename><surname>Zhang</surname></persName><note type="correspondence"><p>Correspondence: Department of Pathology, University of Washington School of Medicine, HMC Box 359635, Seattle, WA 98104.</p></note><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation></author></analytic><monogr><title level="j">Mass Spectrometry Reviews</title><title level="j" type="abbrev">Mass Spectrom. Rev.</title><idno type="pISSN">0277-7037</idno><idno type="eISSN">1098-2787</idno><idno type="DOI">10.1002/(ISSN)1098-2787</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01"></date><biblScope unit="volume">29</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="79">79</biblScope><biblScope unit="page" to="125">125</biblScope></imprint></monogr><idno type="istex">39E49D67A31877FB13570FF15D84333251F02047</idno><idno type="DOI">10.1002/mas.20221</idno><idno type="ArticleID">MAS20221</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry‐based technology to the study of neurodegenerative disorders (e.g., Alzheimer's disease and Parkinson's disease) is relatively new, and is expected to provide insight into the biochemical pathogenesis of neurodegeneration, as well as biomarker discovery. In this review, we have summarized the current understanding of glycoproteins in biology and neurodegenerative disease, and have discussed existing proteomic technologies that are utilized to characterize glycoproteins. Some of the ongoing studies, where glycoproteins isolated from cerebrospinal fluid and human brain are being characterized in Parkinson's disease at different stages versus controls, are presented, along with future applications of targeted validation of brain specific glycoproteins in body fluids. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:79–125, 2010</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>glycoproteomics</term></item><item><term>mass spectrometry</term></item><item><term>Alzheimer's diseases</term></item><item><term>Parkinson's disease</term></item><item><term>biomarkers</term></item><item><term>cerebrospinal fluids</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-10-23">Received</change><change when="2008-12-29">Registration</change><change when="2010-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/39E49D67A31877FB13570FF15D84333251F02047/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1098-2787</doi><issn type="print">0277-7037</issn><issn type="electronic">1098-2787</issn><idGroup><id type="product" value="MAS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MASS SPECTROMETRY REVIEWS">Mass Spectrometry Reviews</title><title type="short">Mass Spectrom. Rev.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/mas.v29:1</doi><numberingGroup><numbering type="journalVolume" number="29">29</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2010-01">January/February 2010</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="50" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mas.20221</doi><idGroup><id type="unit" value="MAS20221"></id></idGroup><countGroup><count type="pageTotal" number="47"></count></countGroup><copyright ownership="publisher">Copyright © 2009 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2008-10-23"></event><event type="manuscriptAccepted" date="2008-12-29"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-04-08"></event><event type="firstOnline" date="2009-04-08"></event><event type="publishedOnlineFinalForm" date="2009-12-22"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">79</numbering><numbering type="pageLast">125</numbering></numberingGroup><correspondenceTo>Department of Pathology, University of Washington School of Medicine, HMC Box 359635, Seattle, WA 98104.</correspondenceTo><objectNameGroup><objectName elementName="appendix">Appendix</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:MAS.MAS20221.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="170"></count><count type="wordTotal" number="11748"></count></countGroup><titleGroup><title type="main" xml:lang="en">Glycoproteomics in neurodegenerative diseases</title><title type="short" xml:lang="en">GLYCOPROTEOMICS IN NEURODEGENERATIVE DISEASES</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Hyejin</givenNames><familyName>Hwang</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jianpeng</givenNames><familyName>Zhang</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Kathryn A.</givenNames><familyName>Chung</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>James B.</givenNames><familyName>Leverenz</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Cyrus P.</givenNames><familyName>Zabetian</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Elaine R.</givenNames><familyName>Peskind</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Joseph</givenNames><familyName>Jankovic</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Zhen</givenNames><familyName>Su</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Aneeka M.</givenNames><familyName>Hancock</familyName></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Catherine</givenNames><familyName>Pan</familyName></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Thomas J.</givenNames><familyName>Montine</familyName></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sheng</givenNames><familyName>Pan</familyName></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af2"><personName><givenNames>John</givenNames><familyName>Nutt</familyName></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Roger</givenNames><familyName>Albin</familyName></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Marla</givenNames><familyName>Gearing</familyName></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Richard P.</givenNames><familyName>Beyer</familyName></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Min</givenNames><familyName>Shi</familyName></personName></creator><creator xml:id="au18" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Jing</givenNames><familyName>Zhang</familyName></personName><contactDetails><email>zhangj@u.washington.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Pathology, University of Washington, Seattle, WA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Baylor College of Medicine, Houston, TX</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Ann Arbor VAMC GRECC and Department of Neurology, University of Michigan, Ann Arbor, MI</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="US" type="organization"><unparsedAffiliation>Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="US" type="organization"><unparsedAffiliation>Department of Environmental & Occupational Health Sciences, University of Washington School of Medicine, Seattle, WA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">glycoproteomics</keyword><keyword xml:id="kwd2">mass spectrometry</keyword><keyword xml:id="kwd3">Alzheimer's diseases</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword><keyword xml:id="kwd5">biomarkers</keyword><keyword xml:id="kwd6">cerebrospinal fluids</keyword></keywordGroup><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>ES012703</fundingNumber><fundingNumber>NS057567</fundingNumber><fundingNumber>AG025327</fundingNumber><fundingNumber>AG033398</fundingNumber><fundingNumber>NS060252</fundingNumber><fundingNumber>AG05136</fundingNumber><fundingNumber>AG08671</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry‐based technology to the study of neurodegenerative disorders (e.g., Alzheimer's disease and Parkinson's disease) is relatively new, and is expected to provide insight into the biochemical pathogenesis of neurodegeneration, as well as biomarker discovery. In this review, we have summarized the current understanding of glycoproteins in biology and neurodegenerative disease, and have discussed existing proteomic technologies that are utilized to characterize glycoproteins. Some of the ongoing studies, where glycoproteins isolated from cerebrospinal fluid and human brain are being characterized in Parkinson's disease at different stages versus controls, are presented, along with future applications of targeted validation of brain specific glycoproteins in body fluids. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:79–125, 2010</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Glycoproteomics in neurodegenerative diseases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>GLYCOPROTEOMICS IN NEURODEGENERATIVE DISEASES</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Glycoproteomics in neurodegenerative diseases</title></titleInfo><name type="personal"><namePart type="given">Hyejin</namePart><namePart type="family">Hwang</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jianpeng</namePart><namePart type="family">Zhang</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathryn A.</namePart><namePart type="family">Chung</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James B.</namePart><namePart type="family">Leverenz</namePart><affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</affiliation><affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cyrus P.</namePart><namePart type="family">Zabetian</namePart><affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elaine R.</namePart><namePart type="family">Peskind</namePart><affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</affiliation><affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph</namePart><namePart type="family">Jankovic</namePart><affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zhen</namePart><namePart type="family">Su</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aneeka M.</namePart><namePart type="family">Hancock</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Catherine</namePart><namePart type="family">Pan</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas J.</namePart><namePart type="family">Montine</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sheng</namePart><namePart type="family">Pan</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="family">Nutt</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roger</namePart><namePart type="family">Albin</namePart><affiliation>Ann Arbor VAMC GRECC and Department of Neurology, University of Michigan, Ann Arbor, MI</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marla</namePart><namePart type="family">Gearing</namePart><affiliation>Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard P.</namePart><namePart type="family">Beyer</namePart><affiliation>Department of Environmental & Occupational Health Sciences, University of Washington School of Medicine, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Min</namePart><namePart type="family">Shi</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jing</namePart><namePart type="family">Zhang</namePart><affiliation>Department of Pathology, University of Washington, Seattle, WA</affiliation><description>Correspondence: Department of Pathology, University of Washington School of Medicine, HMC Box 359635, Seattle, WA 98104.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-01</dateIssued><dateCaptured encoding="w3cdtf">2008-10-23</dateCaptured><dateValid encoding="w3cdtf">2008-12-29</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">170</extent><extent unit="words">11748</extent></physicalDescription><abstract lang="en">Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to systematically profile the glycopeptides or glycoproteins of a complex mixture that are highly enriched in body fluids, and therefore, carry great potential to be diagnostic and/or prognostic markers. Application of this mass spectrometry‐based technology to the study of neurodegenerative disorders (e.g., Alzheimer's disease and Parkinson's disease) is relatively new, and is expected to provide insight into the biochemical pathogenesis of neurodegeneration, as well as biomarker discovery. In this review, we have summarized the current understanding of glycoproteins in biology and neurodegenerative disease, and have discussed existing proteomic technologies that are utilized to characterize glycoproteins. Some of the ongoing studies, where glycoproteins isolated from cerebrospinal fluid and human brain are being characterized in Parkinson's disease at different stages versus controls, are presented, along with future applications of targeted validation of brain specific glycoproteins in body fluids. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:79–125, 2010</abstract><note type="funding">NIH - No. ES012703; No. NS057567; No. AG025327; No. AG033398; No. NS060252; No. AG05136; No. AG08671; </note><subject lang="en"><genre>Keywords</genre><topic>glycoproteomics</topic><topic>mass spectrometry</topic><topic>Alzheimer's diseases</topic><topic>Parkinson's disease</topic><topic>biomarkers</topic><topic>cerebrospinal fluids</topic></subject><relatedItem type="host"><titleInfo><title>Mass Spectrometry Reviews</title></titleInfo><titleInfo type="abbreviated"><title>Mass Spectrom. Rev.</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0277-7037</identifier><identifier type="eISSN">1098-2787</identifier><identifier type="DOI">10.1002/(ISSN)1098-2787</identifier><identifier type="PublisherID">MAS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>79</start><end>125</end><total>47</total></extent></part></relatedItem><identifier type="istex">39E49D67A31877FB13570FF15D84333251F02047</identifier><identifier type="DOI">10.1002/mas.20221</identifier><identifier type="ArticleID">MAS20221</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002153 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002153 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:39E49D67A31877FB13570FF15D84333251F02047
|texte= Glycoproteomics in neurodegenerative diseases
}}
| This area was generated with Dilib version V0.6.23. |  |